Sunday, September 26, 2010

Unconventional NT-Endocannabinoids-Brain's own Marijuana?

Conventional NT is H2O soluble and is stored in high concentration in little packets or vesicles. Unconventional NT like Endocannabinoids are fats and are not stored but synthesized from components of cell membrane. Unconventional neurotransmitters have many exceptions to normal neurotransmitter.1.not stored at synapses [produced locally and used immediately].2.not exocytose [diffuses freely across the membrane] 3.very unstable and reactive.
Scientist have discovered that the brain manufactures protein that act like marijuana at specific receptors in the brain itself.[THC receptor]The main active chemical in marijuana is delta-9-tetrahydro cannabinol;THC for short. Endocannabinoids-retrograde transporters like NO- nitric oxide, and are involved in a variety of physiological processes including appetide, pain sensation, emotion, learning and memory. It is named for endocannabinoids the endogenous lipids that bind cannabinoid receptors CB1 and CB2 located in the CNS and periphery respectively [the same receptors that mediate the psychoactive effects of cannabis.CB1 receptors have been found mainly in the CNS, but also in lymphocytes, ovary, uterus, testes, vas and urinary bladder.CB2 receptors have been identified mainly in immune cells but are expressed also in astrocytes and in the brain stem.

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